Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner

Growth hormone (GH) is a counter-regulatory hormone that plays an important role in preventing hypoglycemia during fasting. Because inhibition of the pyruvate dehydrogenase complex (PDC) by pyruvate dehydrogenase kinase 4 (PDK4) conserves substrates for gluconeogenesis, we tested whether GH increase...

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Detalles Bibliográficos
Autores principales: Kim, Yong Deuk, Kim, Yong-Hoon, Tadi, Surendar, Yu, Ji Hoon, Yim, Yong-Hyeon, Jeoung, Nam Ho, Shong, Minho, Hennighausen, Lothar, Harris, Robert A., Lee, In-Kyu, Lee, Chul-Ho, Choi, Hueng-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447904/
https://www.ncbi.nlm.nih.gov/pubmed/22698918
http://dx.doi.org/10.2337/db11-1665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447904/
https://www.ncbi.nlm.nih.gov/pubmed/22698918
http://dx.doi.org/10.2337/db11-1665

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