Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

Accumulation of toxic lipids evokes the unfolded protein response (UPR) and apoptotic death of macrophages and vascular cells in atherosclerotic plaques. Primary macrophages from insulin-resistant ob/ob and insulin receptor (Insr)(−/−) mice display increased apoptosis in response to loading with fre...

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Detalles Bibliográficos
Autores principales: Liang, Chien-Ping, Han, Seongah, Li, Gang, Tabas, Ira, Tall, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447920/
https://www.ncbi.nlm.nih.gov/pubmed/22751695
http://dx.doi.org/10.2337/db11-1415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447920/
https://www.ncbi.nlm.nih.gov/pubmed/22751695
http://dx.doi.org/10.2337/db11-1415

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