Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding

The homeodomain and adjacent CVC domain in the visual system homeobox (VSX) proteins are conserved from nematodes to humans. Humans with missense mutations in these regions of VSX2 have microphthalmia, suggesting both regions are critical for function. To assess this, we generated the corresponding...

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Detalles Bibliográficos
Autores principales: Zou, Changjiang, Levine, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447932/
https://www.ncbi.nlm.nih.gov/pubmed/23028343
http://dx.doi.org/10.1371/journal.pgen.1002924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447932/
https://www.ncbi.nlm.nih.gov/pubmed/23028343
http://dx.doi.org/10.1371/journal.pgen.1002924

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