Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

Protein kinases use ATP as a phosphoryl donor for the posttranslational modification of signaling targets. It is generally thought that the binding of this nucleotide induces conformational changes leading to closed, more compact forms of the kinase domain that ideally orient active-site residues fo...

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Detalles Bibliográficos
Autores principales: Jamros, Michael A., Oliveira, Leandro C., Whitford, Paul C., Onuchic, José N., Adams, Joseph A., Jennings, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447962/
https://www.ncbi.nlm.nih.gov/pubmed/23028292
http://dx.doi.org/10.1371/journal.pcbi.1002695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447962/
https://www.ncbi.nlm.nih.gov/pubmed/23028292
http://dx.doi.org/10.1371/journal.pcbi.1002695

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