Characterization of Inducible Models of Tay-Sachs and Related Disease

Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system. The molecular events that lead to irreversible neuronal injury accompanied by gliosis are unkno...

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Detalles Bibliográficos
Autores principales: Sargeant, Timothy J., Drage, Deborah J., Wang, Susan, Apostolakis, Apostolos A., Cox, Timothy M., Cachón-González, M. Begoña
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447966/
https://www.ncbi.nlm.nih.gov/pubmed/23028353
http://dx.doi.org/10.1371/journal.pgen.1002943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447966/
https://www.ncbi.nlm.nih.gov/pubmed/23028353
http://dx.doi.org/10.1371/journal.pgen.1002943

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