2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε

In this study we identified two heterocyclic compounds (5 and 6) as potent and specific inhibitors of CK1δ (IC(50) = 0.040 and 0.042 μM, respectively). Whereas compound 5 exhibited fivefold higher affinity towards CK1δ than to CK1ε (IC(50) CK1ε = 0.199 μM), compound 6 also inhibited CK1ε (IC(50) = 0...

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Detalles Bibliográficos
Autores principales: Bischof, Joachim, Leban, Johann, Zaja, Mirko, Grothey, Arnhild, Radunsky, Barbara, Othersen, Olaf, Strobl, Stefan, Vitt, Daniel, Knippschild, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448056/
https://www.ncbi.nlm.nih.gov/pubmed/22331384
http://dx.doi.org/10.1007/s00726-012-1234-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448056/
https://www.ncbi.nlm.nih.gov/pubmed/22331384
http://dx.doi.org/10.1007/s00726-012-1234-x

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