Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

[Image: see text] E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the development of small-molecule inhibitors has proven extraordinarily challenging as mo...

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Detalles Bibliográficos
Autores principales: Buckley, Dennis L., Van Molle, Inge, Gareiss, Peter C., Tae, Hyun Seop, Michel, Julien, Noblin, Devin J., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448299/
https://www.ncbi.nlm.nih.gov/pubmed/22369643
http://dx.doi.org/10.1021/ja209924v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448299/
https://www.ncbi.nlm.nih.gov/pubmed/22369643
http://dx.doi.org/10.1021/ja209924v

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