Cargando…
Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
[Image: see text] E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the development of small-molecule inhibitors has proven extraordinarily challenging as mo...
Autores principales: | Buckley, Dennis L., Van Molle, Inge, Gareiss, Peter C., Tae, Hyun Seop, Michel, Julien, Noblin, Devin J., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2012
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448299/ https://www.ncbi.nlm.nih.gov/pubmed/22369643 http://dx.doi.org/10.1021/ja209924v |
Ejemplares similares
-
Surface Probing
by Fragment-Based Screening and Computational
Methods Identifies Ligandable Pockets on the von Hippel–Lindau
(VHL) E3 Ubiquitin Ligase
por: Lucas, Xavier, et al.
Publicado: (2018) -
Structure-Guided Design and
Optimization of Small
Molecules Targeting the Protein–Protein Interaction between
the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia
Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
por: Galdeano, Carles, et al.
Publicado: (2014) -
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
por: Diehl, Claudia J., et al.
Publicado: (2022) -
Hemangioblast: origin of hemangioblastoma in von Hippel-Lindau (VHL) syndrome
por: Wang, Herui, et al.
Publicado: (2018) -
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis
por: Hudler, Petra, et al.
Publicado: (2022)