Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX

BACKGROUND: Expression of the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein rapidily induces a significant increase of micronuclei (MN) and unstabilized DNA breaks in cells. Unstabilized DNA breaks can have free 3′-OH ends accessible to in situ addition of digoxygenin (DIG)-labeled dUT...

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Detalles Bibliográficos
Autores principales: Majone, Franca, Jeang, Kuan-Teh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448514/
https://www.ncbi.nlm.nih.gov/pubmed/22541714
http://dx.doi.org/10.1186/2045-3701-2-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448514/
https://www.ncbi.nlm.nih.gov/pubmed/22541714
http://dx.doi.org/10.1186/2045-3701-2-15

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