Conditional Mesenchymal Disruption of Pkd1 Results in Osteopenia and Polycystic Kidney Disease

Conditional deletion of Pkd1 in osteoblasts using either Osteocalcin(Oc)-Cre or Dmp1-Cre results in defective osteoblast-mediated postnatal bone formation and osteopenia. Pkd1 is also expressed in undifferentiated mesenchyme that gives rise to the osteoblast lineage. To examine the effects of Pkd1 o...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Ni, Xiao, Zhousheng, Cao, Li, David, Valentin, Quarles, Leigh Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448720/
https://www.ncbi.nlm.nih.gov/pubmed/23029375
http://dx.doi.org/10.1371/journal.pone.0046038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448720/
https://www.ncbi.nlm.nih.gov/pubmed/23029375
http://dx.doi.org/10.1371/journal.pone.0046038

Ejemplares similares