Autistic behavior in Scn1a(+/−) mice and rescue by enhanced GABAergic transmission

Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel Na(V)1.1 causes Dravet Syndrome (DS), a childhood neuropsychiatric disorder including recurrent intractable seizures, cognitive deficit, and autism-spectrum behaviors. The neural mechanisms responsible for cognitive deficit a...

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Detalles Bibliográficos
Autores principales: Han, Sung, Tai, Chao, Westenbroek, Ruth E., Yu, Frank H., Cheah, Christine S., Potter, Gregory B., Rubenstein, John L., Scheuer, Todd, de la Iglesia, Horacio O, Catterall, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448848/
https://www.ncbi.nlm.nih.gov/pubmed/22914087
http://dx.doi.org/10.1038/nature11356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448848/
https://www.ncbi.nlm.nih.gov/pubmed/22914087
http://dx.doi.org/10.1038/nature11356

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