Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

Neurogenesis requires negative regulation through differentiation of progenitors or their programmed cell death (PCD). Growth regulation is particularly important in the postnatal cerebellum, where excessive progenitor proliferation promotes medulloblastoma, the most common malignant brain tumor in...

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Detalles Bibliográficos
Autores principales: Garcia, Idoia, Crowther, Andrew J., Gama, Vivian, Miller, C. Ryan, Deshmukh, Mohanish, Gershon, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449008/
https://www.ncbi.nlm.nih.gov/pubmed/22710714
http://dx.doi.org/10.1038/onc.2012.248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449008/
https://www.ncbi.nlm.nih.gov/pubmed/22710714
http://dx.doi.org/10.1038/onc.2012.248

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