Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity

Following the initial diversity generated by V(D)J recombination, somatic hypermutation is the principal mechanism for producing further antibody repertoire diversity in antigen-experienced B cells. While somatic hypermutation typically results in single nucleotide substitutions, the infrequent inco...

Descripción completa

Detalles Bibliográficos
Autores principales: Briney, Bryan S., Willis, Jordan R., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449029/
https://www.ncbi.nlm.nih.gov/pubmed/22717702
http://dx.doi.org/10.1038/gene.2012.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449029/
https://www.ncbi.nlm.nih.gov/pubmed/22717702
http://dx.doi.org/10.1038/gene.2012.28

Ejemplares similares