Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12

Metastatic cell migration and invasion are regulated by altered adhesion-mediated signaling to the actin-based cytoskeleton via activated Src-FAK complexes. SSeCKS (the rodent orthologue of human Gravin/AKAP12), whose expression is downregulated by oncogenic Src and in many human cancers, antagonize...

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Detalles Bibliográficos
Autores principales: Su, Bing, Gao, Lingqiu, Meng, Fanjie, Guo, Li-wu, Rothschild, Julian, Gelman, Irwin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449054/
https://www.ncbi.nlm.nih.gov/pubmed/22710722
http://dx.doi.org/10.1038/onc.2012.218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449054/
https://www.ncbi.nlm.nih.gov/pubmed/22710722
http://dx.doi.org/10.1038/onc.2012.218

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