Improved drug-like properties of therapeutic proteins by directed evolution

Many natural human proteins have functional properties that make them useful as therapeutic drugs. However, not all these proteins are compatible with large-scale manufacturing processes or sufficiently stable to be stored for long periods prior to use. In this study, we focus on small four-helix bu...

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Detalles Bibliográficos
Autores principales: Buchanan, Andrew, Ferraro, Franco, Rust, Steven, Sridharan, Sudharsan, Franks, Ruth, Dean, Greg, McCourt, Matthew, Jermutus, Lutz, Minter, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449403/
https://www.ncbi.nlm.nih.gov/pubmed/22942395
http://dx.doi.org/10.1093/protein/gzs054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449403/
https://www.ncbi.nlm.nih.gov/pubmed/22942395
http://dx.doi.org/10.1093/protein/gzs054

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