Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

We have designed bispecific antibodies that bind one target (anti-Her3) in a bivalent IgG-like manner and contain one additional binding entity (anti-cMet) composed of one V(H) and one V(L) domain connected by a disulfide bond. The molecules are assembled by fusing a V(H,Cys44) domain via flexible c...

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Detalles Bibliográficos
Autores principales: Metz, Silke, Panke, Christian, Haas, Alexander K., Schanzer, Jürgen, Lau, Wilma, Croasdale, Rebecca, Hoffmann, Eike, Schneider, Britta, Auer, Johannes, Gassner, Christian, Bossenmaier, Birgit, Umana, Pablo, Sustmann, Claudio, Brinkmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449404/
https://www.ncbi.nlm.nih.gov/pubmed/22976197
http://dx.doi.org/10.1093/protein/gzs064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449404/
https://www.ncbi.nlm.nih.gov/pubmed/22976197
http://dx.doi.org/10.1093/protein/gzs064

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