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The Identification of a Novel Gene, MAPO2, That Is Involved in the Induction of Apoptosis Triggered by O(6)-Methylguanine
O(6)-Methylguanine, one of alkylated DNA bases, is especially mutagenic. Cells containing this lesion are eliminated by induction of apoptosis, associated with the function of mismatch repair (MMR) proteins. A retrovirus-mediated gene-trap mutagenesis was used to isolate new genes related to the ind...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454368/ https://www.ncbi.nlm.nih.gov/pubmed/23028632 http://dx.doi.org/10.1371/journal.pone.0044817 |