The Unique Cysteine Knot Regulates the Pleotropic Hormone Leptin

Leptin plays a key role in regulating energy intake/expenditure, metabolism and hypertension. It folds into a four-helix bundle that binds to the extracellular receptor to initiate signaling. Our work on leptin revealed a hidden complexity in the formation of a previously un-described, cysteine-knot...

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Detalles Bibliográficos
Autores principales: Haglund, Ellinor, Sułkowska, Joanna I., He, Zhao, Feng, Gen-Sheng, Jennings, Patricia A., Onuchic, José N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454405/
https://www.ncbi.nlm.nih.gov/pubmed/23029163
http://dx.doi.org/10.1371/journal.pone.0045654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454405/
https://www.ncbi.nlm.nih.gov/pubmed/23029163
http://dx.doi.org/10.1371/journal.pone.0045654

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