Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin

G-protein-coupled receptors are universally regulated by arrestin binding. Here we show that rod arrestin induces uptake of the agonist all-trans-retinol in only half the population of phosphorylated opsin in the native membrane. Agonist uptake blocks subsequent entry of the inverse agonist 11-cis-r...

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Detalles Bibliográficos
Autores principales: Sommer, Martha E., Hofmann, Klaus Peter, Heck, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455371/
https://www.ncbi.nlm.nih.gov/pubmed/22871814
http://dx.doi.org/10.1038/ncomms2000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455371/
https://www.ncbi.nlm.nih.gov/pubmed/22871814
http://dx.doi.org/10.1038/ncomms2000

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