Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivity

Voltage-gated Na(+) channels (NaV channels) are specifically blocked by guanidinium toxins such as tetrodotoxin (TTX) and saxitoxin (STX) with nanomolar to micromolar affinity depending on key amino acid substitutions in the outer vestibule of the channel that vary with NaV gene isoforms. All NaV ch...

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Detalles Bibliográficos
Autores principales: Huang, Chien-Jung, Schild, Laurent, Moczydlowski, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457692/
https://www.ncbi.nlm.nih.gov/pubmed/23008436
http://dx.doi.org/10.1085/jgp.201210853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457692/
https://www.ncbi.nlm.nih.gov/pubmed/23008436
http://dx.doi.org/10.1085/jgp.201210853

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