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Simulated annealing reveals the kinetic activity of SGLT1, a member of the LeuT structural family

The Na(+)/glucose cotransporter (SGLT1) is the archetype of membrane proteins that use the electrochemical Na(+) gradient to drive uphill transport of a substrate. The crystal structure recently obtained for vSGLT strongly suggests that SGLT1 adopts the inverted repeat fold of the LeuT structural fa...

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Detalles Bibliográficos
Autores principales: Longpré, Jean-Philippe, Sasseville, Louis J., Lapointe, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457693/
https://www.ncbi.nlm.nih.gov/pubmed/23008432
http://dx.doi.org/10.1085/jgp.201210822