Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this study, we have found for the first time that SU5416 unexpectedly prevented 1-methyl-4-phenylpyridinium ion (MPP(+))-induced neuronal apoptosis in...

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Detalles Bibliográficos
Autores principales: Cui, Wei, Zhang, Zaijun, Li, Wenming, Mak, Shinghung, Hu, Shengquan, Zhang, Huan, Yuan, Shuai, Rong, Jianhui, Choi, Tony Chunglit, Lee, Simon M. Y., Han, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457988/
https://www.ncbi.nlm.nih.gov/pubmed/23049997
http://dx.doi.org/10.1371/journal.pone.0046253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457988/
https://www.ncbi.nlm.nih.gov/pubmed/23049997
http://dx.doi.org/10.1371/journal.pone.0046253

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