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Paralogous ALT1 and ALT2 Retention and Diversification Have Generated Catalytically Active and Inactive Aminotransferases in Saccharomyces cerevisiae
BACKGROUND: Gene duplication and the subsequent divergence of paralogous pairs play a central role in the evolution of novel gene functions. S. cerevisiae possesses two paralogous genes (ALT1/ALT2) which presumably encode alanine aminotransferases. It has been previously shown that Alt1 encodes an a...
Autores principales: | Peñalosa-Ruiz, Georgina, Aranda, Cristina, Ongay-Larios, Laura, Colon, Maritrini, Quezada, Hector, Gonzalez, Alicia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458083/ https://www.ncbi.nlm.nih.gov/pubmed/23049841 http://dx.doi.org/10.1371/journal.pone.0045702 |
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