Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Lepti...

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Detalles Bibliográficos
Autores principales: Huang, Hu, Kong, Dong, Byun, Kyung Hee, Ye, Chianping, Koda, Shuichi, Lee, Dae Ho, Oh, Byung-Chul, Lee, Sam W, Lee, Bonghee, Zabolotny, Janice M, Kim, Min Seon, Bjørbæk, Christian, Lowell, Bradford B, Kim, Young-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458121/
https://www.ncbi.nlm.nih.gov/pubmed/22941110
http://dx.doi.org/10.1038/nn.3207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458121/
https://www.ncbi.nlm.nih.gov/pubmed/22941110
http://dx.doi.org/10.1038/nn.3207

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