Cargando…

Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Lepti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hu, Kong, Dong, Byun, Kyung Hee, Ye, Chianping, Koda, Shuichi, Lee, Dae Ho, Oh, Byung-Chul, Lee, Sam W, Lee, Bonghee, Zabolotny, Janice M, Kim, Min Seon, Bjørbæk, Christian, Lowell, Bradford B, Kim, Young-Bum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458121/ https://www.ncbi.nlm.nih.gov/pubmed/22941110 http://dx.doi.org/10.1038/nn.3207

Ejemplares similares

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
por: Gamber, Kevin M., et al.
Publicado: (2012)

Hypothalamic TTF-1 orchestrates the sensitivity of leptin
por: Park, Byong Seo, et al.
Publicado: (2022)

Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior
por: Jeong, Bora, et al.
Publicado: (2022)

Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
por: Ahn, Sung Yeon, et al.
Publicado: (2012)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents
por: Perry, Rachel J., et al.
Publicado: (2019)

Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance
por: Kim, Jaedeok, et al.
Publicado: (2022)

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation
por: Lee, Chan Hee, et al.
Publicado: (2018)

Tanycyte-Independent Control of Hypothalamic Leptin Signaling
por: Yoo, Sooyeon, et al.
Publicado: (2019)

Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation
por: Stein, Lauren M., et al.
Publicado: (2020)

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance
por: Rupp, Alan C., et al.
Publicado: (2018)

Leptin action via hypothalamic nitric oxide synthase-1 neurons controls energy balance
por: Leshan, Rebecca L., et al.
Publicado: (2012)

Environment, Leptin Sensitivity, and Hypothalamic Plasticity
por: Mainardi, Marco, et al.
Publicado: (2013)

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
por: Kim, Hyun-Kyong, et al.
Publicado: (2010)

Hypothalamic Leptin Resistance: From BBB to BBSome
por: López, Miguel
Publicado: (2016)

Hypothalamic PKA regulates leptin sensitivity and adiposity
por: Yang, Linghai, et al.
Publicado: (2015)

Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons
por: Sohn, Jong-Woo, et al.
Publicado: (2016)

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
por: Lee, Seung-Hwan, et al.
Publicado: (2016)

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
por: Park, Soyoung, et al.
Publicado: (2020)

Leptin Increases: Physiological Roles in the Control of Sympathetic Nerve Activity, Energy Balance, and the Hypothalamic–Pituitary–Thyroid Axis
por: Martelli, Davide, et al.
Publicado: (2023)

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice
por: Lee, Young Hee, et al.
Publicado: (2023)

Hypothalamic leptin action is mediated by histone deacetylase 5
por: Kabra, Dhiraj G., et al.
Publicado: (2016)

Cellular Contributors to Hypothalamic Inflammation in Obesity
por: Lee, Chan Hee, et al.
Publicado: (2020)

Hypothalamic lipophagy and energetic balance
por: Singh, Rajat
Publicado: (2011)

Hypothalamic AMPK and energy balance
por: López, Miguel
Publicado: (2018)

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
por: Rahmouni, Kamal, et al.
Publicado: (2009)

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin
por: Fruhwürth, Stefanie, et al.
Publicado: (2018)

Implications of the RhoA/Rho associated kinase pathway and leptin in primary uterine inertia in the dog
por: FREHNER, Bianca Lourdes, et al.
Publicado: (2021)

Induced pluripotent stem cells and personalized medicine: current progress and future perspectives
por: Chun, Yong Soon, et al.
Publicado: (2011)

Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons
por: Oh, Seyeon, et al.
Publicado: (2019)

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance
por: Chang, Bo, et al.
Publicado: (2021)

OR12-06 Hypothalamic Adgrl1 Is A Potential Glucoreceptor Involved In Regulating Energy Balance, Glucose Homeostasis, And Leptin Sensitivity In Mice
por: Samuel, Dennis J, et al.
Publicado: (2023)

Interglial Crosstalk in Obesity-Induced Hypothalamic Inflammation
por: Rahman, Md Habibur, et al.
Publicado: (2018)

Effects of Hypothalamic Neurodegeneration on Energy Balance
por: Xu, Allison Wanting, et al.
Publicado: (2005)

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling
por: Tam, Joseph, et al.
Publicado: (2017)

Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration
por: Brown, Juliette A., et al.
Publicado: (2019)

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity
por: Zheng, Hong, et al.
Publicado: (2017)

A leptin-responsive hypothalamic circuit inputs to the circadian feeding network
por: Tang, Qijun, et al.
Publicado: (2023)

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite
por: Kim, Sang-Yeob, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7tgidrcpcaikd1nuhhia4sfe9s