Mitochondrial Hormesis in Pancreatic β Cells: Does Uncoupling Protein 2 Play a Role?

In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondr...

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Detalles Bibliográficos
Autores principales: Li, Ning, Stojanovski, Suzana, Maechler, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458419/
https://www.ncbi.nlm.nih.gov/pubmed/23029600
http://dx.doi.org/10.1155/2012/740849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458419/
https://www.ncbi.nlm.nih.gov/pubmed/23029600
http://dx.doi.org/10.1155/2012/740849

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