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Mitochondrial Hormesis in Pancreatic β Cells: Does Uncoupling Protein 2 Play a Role?
In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458419/ https://www.ncbi.nlm.nih.gov/pubmed/23029600 http://dx.doi.org/10.1155/2012/740849 |