Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

Double-strand breaks (DSBs) are repaired by two distinct pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). The endonuclease Artemis and the PIK kinase Ataxia-Telangiectasia Mutated (ATM), mutated in prominent human radiosensitivity syndromes, are essential for repairing...

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Detalles Bibliográficos
Autores principales: Köcher, Sabrina, Rieckmann, Thorsten, Rohaly, Gabor, Mansour, Wael Y., Dikomey, Ekkehard, Dornreiter, Irena, Dahm-Daphi, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458552/
https://www.ncbi.nlm.nih.gov/pubmed/22730303
http://dx.doi.org/10.1093/nar/gks604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458552/
https://www.ncbi.nlm.nih.gov/pubmed/22730303
http://dx.doi.org/10.1093/nar/gks604

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