Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomer...

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Detalles Bibliográficos
Autores principales: Leng, Bo, Chichetti, Stephanie, Su, Shun, Beeler, Aaron B, Porco, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458758/
https://www.ncbi.nlm.nih.gov/pubmed/23019468
http://dx.doi.org/10.3762/bjoc.8.153
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author Leng, Bo
Chichetti, Stephanie
Su, Shun
Beeler, Aaron B
Porco, John A
author_facet Leng, Bo
Chichetti, Stephanie
Su, Shun
Beeler, Aaron B
Porco, John A
author_sort Leng, Bo
collection PubMed
description Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.
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spelling pubmed-34587582012-09-27 Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations Leng, Bo Chichetti, Stephanie Su, Shun Beeler, Aaron B Porco, John A Beilstein J Org Chem Full Research Paper Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization. Beilstein-Institut 2012-08-20 /pmc/articles/PMC3458758/ /pubmed/23019468 http://dx.doi.org/10.3762/bjoc.8.153 Text en Copyright © 2012, Leng et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Leng, Bo
Chichetti, Stephanie
Su, Shun
Beeler, Aaron B
Porco, John A
Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title_full Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title_fullStr Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title_full_unstemmed Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title_short Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
title_sort synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458758/
https://www.ncbi.nlm.nih.gov/pubmed/23019468
http://dx.doi.org/10.3762/bjoc.8.153
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