A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach. Alternative methods of macrolactonization (e.g., Corey–Nicolaou) resulted in significant epimerization of the C-terminal amino acid during t...

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Detalles Bibliográficos
Autores principales: Cochrane, James R, Yoon, Dong Hee, McErlean, Christopher S P, Jolliffe, Katrina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458759/
https://www.ncbi.nlm.nih.gov/pubmed/23019469
http://dx.doi.org/10.3762/bjoc.8.154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458759/
https://www.ncbi.nlm.nih.gov/pubmed/23019469
http://dx.doi.org/10.3762/bjoc.8.154

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