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N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters

An efficient catalytic synthesis of α-amino-β-keto esters has been newly developed. Cross-coupling of various aldehydes with α-imino ester, catalyzed by N-heterocyclic carbene, leads chemoselectively to α-amino-β-keto esters in moderate to good yields with high atom efficiency. The reaction mechanis...

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Detalles Bibliográficos
Autores principales: Uno, Takuya, Kobayashi, Yusuke, Takemoto, Yoshiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458774/
https://www.ncbi.nlm.nih.gov/pubmed/23019484
http://dx.doi.org/10.3762/bjoc.8.169