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Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats

BACKGROUND: Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes. Although mild or moderate hypoglycemia is not life-threatening, if recurrent, it may cause cognitive impairment. In the present study, we sought to determine whether R/M hypoglycemia leads to neuronal death, dendritic in...

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Detalles Bibliográficos
Autores principales: Won, Seok Joon, Yoo, Byung Hoon, Kauppinen, Tiina M, Choi, Bo Young, Kim, Jin Hee, Jang, Bong Geom, Lee, Min Woo, Sohn, Min, Liu, Jialing, Swanson, Raymond A, Suh, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458941/
https://www.ncbi.nlm.nih.gov/pubmed/22830525
http://dx.doi.org/10.1186/1742-2094-9-182