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Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

BACKGROUND: Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex. Neuroinflammation is also present, but its role in AD is not fully understood. We previously showed increased level...

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Detalles Bibliográficos
Autores principales: Sutinen, Elina M, Pirttilä, Tuula, Anderson, George, Salminen, Antero, Ojala, Johanna O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458954/
https://www.ncbi.nlm.nih.gov/pubmed/22898493
http://dx.doi.org/10.1186/1742-2094-9-199