Quantification of Ligand Binding to G-Protein Coupled Receptors on Cell Membranes by Ellipsometry

G-protein-coupled receptors (GPCRs) are prime drug targets and targeted by approximately 60% of current therapeutic drugs such as β-blockers, antipsychotics and analgesics. However, no biophysical methods are available to quantify their interactions with ligand binding in a native environment. Here,...

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Detalles Bibliográficos
Autores principales: Kriechbaumer, Verena, Nabok, Alexei, Widdowson, Robert, Smith, David P., Abell, Ben M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458955/
https://www.ncbi.nlm.nih.gov/pubmed/23049983
http://dx.doi.org/10.1371/journal.pone.0046221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458955/
https://www.ncbi.nlm.nih.gov/pubmed/23049983
http://dx.doi.org/10.1371/journal.pone.0046221

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