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Quantification of Ligand Binding to G-Protein Coupled Receptors on Cell Membranes by Ellipsometry
G-protein-coupled receptors (GPCRs) are prime drug targets and targeted by approximately 60% of current therapeutic drugs such as β-blockers, antipsychotics and analgesics. However, no biophysical methods are available to quantify their interactions with ligand binding in a native environment. Here,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458955/ https://www.ncbi.nlm.nih.gov/pubmed/23049983 http://dx.doi.org/10.1371/journal.pone.0046221 |