Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency

The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3. Here we investigate whether Jak/Stat3 may also contribute to induction of pluripotency. EpiSCs derived from postimpla...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jian, van Oosten, Anouk L., Theunissen, Thorold W., Guo, Ge, Silva, Jose C.R., Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459098/
https://www.ncbi.nlm.nih.gov/pubmed/20804969
http://dx.doi.org/10.1016/j.stem.2010.06.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459098/
https://www.ncbi.nlm.nih.gov/pubmed/20804969
http://dx.doi.org/10.1016/j.stem.2010.06.022

Ejemplares similares