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Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review som...

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Detalles Bibliográficos
Autores principales: Kumar, Rakesh K., Foster, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459343/
https://www.ncbi.nlm.nih.gov/pubmed/23060800
http://dx.doi.org/10.3389/fphys.2012.00312