Induction and molecular signature of pathogenic T(H)17 cells

Interleukin 17 (IL-17)-producing T(H)17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that T(H)17 are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic, in fact T(H)17 generated with TGF-β1 an...

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Autores principales: Lee, Youjin, Awasthi, Amit, Yosef, Nir, Quintana, Francisco J., Xiao, Sheng, Peters, Anneli, Wu, Chuan, Kleinewietfeld, Markus, Kunder, Sharon, Hafler, David, Sobel, Raymond A., Regev, Aviv, Kuchroo, Vijay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459594/
https://www.ncbi.nlm.nih.gov/pubmed/22961052
http://dx.doi.org/10.1038/ni.2416
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author Lee, Youjin
Awasthi, Amit
Yosef, Nir
Quintana, Francisco J.
Xiao, Sheng
Peters, Anneli
Wu, Chuan
Kleinewietfeld, Markus
Kunder, Sharon
Hafler, David
Sobel, Raymond A.
Regev, Aviv
Kuchroo, Vijay K.
author_facet Lee, Youjin
Awasthi, Amit
Yosef, Nir
Quintana, Francisco J.
Xiao, Sheng
Peters, Anneli
Wu, Chuan
Kleinewietfeld, Markus
Kunder, Sharon
Hafler, David
Sobel, Raymond A.
Regev, Aviv
Kuchroo, Vijay K.
author_sort Lee, Youjin
collection PubMed
description Interleukin 17 (IL-17)-producing T(H)17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that T(H)17 are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic, in fact T(H)17 generated with TGF-β1 and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we show that TGF-β3, produced by developing T(H)17 cells, is dependent on IL-23, which together with IL-6 induces highly pathogenic T(H)17 cells. Moreover, TGF-β3-induced T(H)17 cells are functionally and molecularly distinct from TGF-β1-induced T(H)17 cells and possess a molecular signature that defines pathogenic effector T(H)17 cells in autoimmune disease.
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spelling pubmed-34595942013-04-01 Induction and molecular signature of pathogenic T(H)17 cells Lee, Youjin Awasthi, Amit Yosef, Nir Quintana, Francisco J. Xiao, Sheng Peters, Anneli Wu, Chuan Kleinewietfeld, Markus Kunder, Sharon Hafler, David Sobel, Raymond A. Regev, Aviv Kuchroo, Vijay K. Nat Immunol Article Interleukin 17 (IL-17)-producing T(H)17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that T(H)17 are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic, in fact T(H)17 generated with TGF-β1 and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we show that TGF-β3, produced by developing T(H)17 cells, is dependent on IL-23, which together with IL-6 induces highly pathogenic T(H)17 cells. Moreover, TGF-β3-induced T(H)17 cells are functionally and molecularly distinct from TGF-β1-induced T(H)17 cells and possess a molecular signature that defines pathogenic effector T(H)17 cells in autoimmune disease. 2012-09-09 2012-10 /pmc/articles/PMC3459594/ /pubmed/22961052 http://dx.doi.org/10.1038/ni.2416 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lee, Youjin
Awasthi, Amit
Yosef, Nir
Quintana, Francisco J.
Xiao, Sheng
Peters, Anneli
Wu, Chuan
Kleinewietfeld, Markus
Kunder, Sharon
Hafler, David
Sobel, Raymond A.
Regev, Aviv
Kuchroo, Vijay K.
Induction and molecular signature of pathogenic T(H)17 cells
title Induction and molecular signature of pathogenic T(H)17 cells
title_full Induction and molecular signature of pathogenic T(H)17 cells
title_fullStr Induction and molecular signature of pathogenic T(H)17 cells
title_full_unstemmed Induction and molecular signature of pathogenic T(H)17 cells
title_short Induction and molecular signature of pathogenic T(H)17 cells
title_sort induction and molecular signature of pathogenic t(h)17 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459594/
https://www.ncbi.nlm.nih.gov/pubmed/22961052
http://dx.doi.org/10.1038/ni.2416
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