Estrogen and Progesterone Regulate p27kip1 Levels via the Ubiquitin-Proteasome System: Pathogenic and Therapeutic Implications for Endometrial Cancer

The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitin-proteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks the cell cycle in G1, is ubiquitylated by the E3...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Kuang-Tzu, Pavlides, Savvas C., Lecanda, Jon, Blank, Stephanie V., Mittal, Khushbakhat R., Gold, Leslie I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459846/
https://www.ncbi.nlm.nih.gov/pubmed/23029392
http://dx.doi.org/10.1371/journal.pone.0046072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459846/
https://www.ncbi.nlm.nih.gov/pubmed/23029392
http://dx.doi.org/10.1371/journal.pone.0046072

Ejemplares similares