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Estrogen and Progesterone Regulate p27kip1 Levels via the Ubiquitin-Proteasome System: Pathogenic and Therapeutic Implications for Endometrial Cancer

The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitin-proteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks the cell cycle in G1, is ubiquitylated by the E3...

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Detalles Bibliográficos
Autores principales:	Huang, Kuang-Tzu, Pavlides, Savvas C., Lecanda, Jon, Blank, Stephanie V., Mittal, Khushbakhat R., Gold, Leslie I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459846/ https://www.ncbi.nlm.nih.gov/pubmed/23029392 http://dx.doi.org/10.1371/journal.pone.0046072

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