Hit-to-Lead Development of the Chamigrane Endoperoxide Merulin A for the Treatment of African Sleeping Sickness

BACKGROUND: Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. Most current treatments have poor blood brain barrier (BBB) penetration, which prevent them from targeting the most lethal stage of the infect...

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Detalles Bibliográficos
Autores principales: Navarro, Gabriel, Chokpaiboon, Supchar, De Muylder, Geraldine, Bray, Walter M., Nisam, Sean C., McKerrow, James H., Pudhom, Khanitha, Linington, Roger G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459870/
https://www.ncbi.nlm.nih.gov/pubmed/23029428
http://dx.doi.org/10.1371/journal.pone.0046172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459870/
https://www.ncbi.nlm.nih.gov/pubmed/23029428
http://dx.doi.org/10.1371/journal.pone.0046172

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