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Enhancing the Prioritization of Disease-Causing Genes through Tissue Specific Protein Interaction Networks
The prioritization of candidate disease-causing genes is a fundamental challenge in the post-genomic era. Current state of the art methods exploit a protein-protein interaction (PPI) network for this task. They are based on the observation that genes causing phenotypically-similar diseases tend to l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459874/ https://www.ncbi.nlm.nih.gov/pubmed/23028288 http://dx.doi.org/10.1371/journal.pcbi.1002690 |