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Convergent Transmission of RNAi Guide-Target Mismatch Information across Argonaute Internal Allosteric Network

In RNA interference, a guide strand derived from a short dsRNA such as a microRNA (miRNA) is loaded into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messenger RNAs on a sequence-specific basis. The positions of any mismatched base pairs in an miRNA determ...

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Detalles Bibliográficos
Autores principales: Joseph, Thomas T., Osman, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459882/
https://www.ncbi.nlm.nih.gov/pubmed/23028290
http://dx.doi.org/10.1371/journal.pcbi.1002693