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Convergent Transmission of RNAi Guide-Target Mismatch Information across Argonaute Internal Allosteric Network
In RNA interference, a guide strand derived from a short dsRNA such as a microRNA (miRNA) is loaded into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messenger RNAs on a sequence-specific basis. The positions of any mismatched base pairs in an miRNA determ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459882/ https://www.ncbi.nlm.nih.gov/pubmed/23028290 http://dx.doi.org/10.1371/journal.pcbi.1002693 |