Limited Phenotypic Effects of Selectively Augmenting the SMN Protein in the Neurons of a Mouse Model of Severe Spinal Muscular Atrophy

The selective vulnerability of motor neurons to paucity of Survival Motor Neuron (SMN) protein is a defining feature of human spinal muscular atrophy (SMA) and indicative of a unique requirement for adequate levels of the protein in these cells. However, the relative contribution of SMN-depleted mot...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Andrew J-H., Awano, Tomoyuki, Park, Gyu-Hwan, Monani, Umrao R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459898/
https://www.ncbi.nlm.nih.gov/pubmed/23029491
http://dx.doi.org/10.1371/journal.pone.0046353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459898/
https://www.ncbi.nlm.nih.gov/pubmed/23029491
http://dx.doi.org/10.1371/journal.pone.0046353

Ejemplares similares