Cargando…

Denatured G-Protein Coupled Receptors as Immunogens to Generate Highly Specific Antibodies

G-protein coupled receptors (GPCRs) play a major role in a number of physiological and pathological processes. Thus, GPCRs have become the most frequent targets for development of new therapeutic drugs. In this context, the availability of highly specific antibodies may be decisive to obtain reliabl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Talmont, Franck, Moulédous, Lionel, Boué, Jérôme, Mollereau, Catherine, Dietrich, Gilles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459905/ https://www.ncbi.nlm.nih.gov/pubmed/23029489 http://dx.doi.org/10.1371/journal.pone.0046348

Ejemplares similares

Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors
por: Talmont, Franck, et al.
Publicado: (2019)

HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
por: Fritzwanker, Sebastian, et al.
Publicado: (2021)

STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
por: Wright, George G.
Publicado: (1945)

Plectoneme tip bubbles: Coupled denaturation and writhing in supercoiled DNA
por: Matek, Christian, et al.
Publicado: (2015)

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states
por: Heimann, Andrea S., et al.
Publicado: (2017)

Denaturing the Lionfish
por: Hobday, Dorian, et al.
Publicado: (2016)

Tungsten-Induced Denaturation and Aggregation of Epoetin Alfa During Primary Packaging as a Cause of Immunogenicity
por: Seidl, Andreas, et al.
Publicado: (2011)

STUDIES ON THE DENATURATION OF ANTIBODY : I. THE ACTION OF UREA ON DIPHTHERIA ANTITOXIN
por: Wright, George G.
Publicado: (1944)

Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states
por: Heimann, Andrea S., et al.
Publicado: (2018)

DNA G-quadruplexes are uniquely stable in the presence of denaturants and monovalent cations
por: Hoog, Tanner G., et al.
Publicado: (2022)

Roles of the ubiquitin proteasome system in the effects of drugs of abuse
por: Massaly, Nicolas, et al.
Publicado: (2015)

THE REVERSIBLE HEAT DENATURATION OF CHYMOTRYPSINOGEN
por: Eisenberg, Max A., et al.
Publicado: (1951)

The incipient denaturation mechanism of DNA
por: Xu, Min, et al.
Publicado: (2022)

Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels
por: Hutchings, Catherine J
Publicado: (2020)

HEAT DENATURATION STUDIES OF RAT LIVER MITOCHONDRIAL DNA : A Denaturation Map and Changes in Molecular Configurations
por: Wolstenholme, David R., et al.
Publicado: (1972)

Comparative Production Analysis of Three Phlebovirus Nucleoproteins under Denaturing or Non-Denaturing Conditions for Crystallographic Studies
por: Lantez, Violaine, et al.
Publicado: (2011)

Predicting the Coupling Specificity of G-protein Coupled Receptors to G-proteins by Support Vector Machines
por: Guan, Cui-Ping, et al.
Publicado: (2005)

Salt-Specific Suppression of the Cold Denaturation of Thermophilic Multidomain Initiation Factor 2
por: Džupponová, Veronika, et al.
Publicado: (2023)

Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts
por: Talmont, Franck, et al.
Publicado: (2022)

THE REACTIONS OF DENATURED EGG ALBUMIN WITH FERRICYANIDE
por: Anson, M. L.
Publicado: (1939)

SENSITIZATION TO DENATURED AUTOLOGOUS GAMMA GLOBULIN
por: McCluskey, Robert T., et al.
Publicado: (1962)

ON THE RELATION OF NECROSIS AND INFLAMMATION TO DENATURATION OF PROTEINS
por: Opie, Eugene L.
Publicado: (1962)

THE EFFECT OF DENATURATION ON THE VISCOSITY OF PROTEIN SYSTEMS
por: Anson, M. L., et al.
Publicado: (1932)

Hysteresis in Pressure-Driven DNA Denaturation
por: Hernández-Lemus, Enrique, et al.
Publicado: (2012)

Single-molecule chemical denaturation of riboswitches
por: Dalgarno, Paul A., et al.
Publicado: (2013)

Protein Unfolding: Denaturant vs. Force
por: Kelly, Colleen, et al.
Publicado: (2021)

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence
por: Nadai, Yuka, et al.
Publicado: (2019)

THE EQUILIBRIA BETWEEN NATIVE AND DENATURED HEMOGLOBIN IN SALICYLATE SOLUTIONS AND THE THEORETICAL CONSEQUENCES OF THE EQUILIBRIUM BETWEEN NATIVE AND DENATURED PROTEIN
por: Anson, M. L., et al.
Publicado: (1934)

Microcalorimetry reveals multi-state thermal denaturation of G. stearothermophilus tryptophanyl-tRNA synthetase
por: Chandrasekaran, Srinivas Niranj, et al.
Publicado: (2023)

Engineering therapeutic antibodies targeting G-protein–coupled receptors
por: Jo, Migyeong, et al.
Publicado: (2016)

Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens
por: Hatano, Ryo, et al.
Publicado: (2019)

Next-generation sequencing of dsRNA is greatly improved by treatment with the inexpensive denaturing reagent DMSO
por: Wilcox, Alexander H., et al.
Publicado: (2019)

Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice
por: Egli, Jerome, et al.
Publicado: (2022)

Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine
por: Gao, Haiyang, et al.
Publicado: (2017)

Protein Denaturants at Aqueous–Hydrophobic Interfaces: Self-Consistent Correlation between Induced Interfacial Fluctuations and Denaturant Stability at the Interface
por: Cui, Di, et al.
Publicado: (2014)

Protecting role of cosolvents in protein denaturation by SDS: a structural study
por: Michaux, Catherine, et al.
Publicado: (2008)

Doses of Immunogen Contribute to Specificity Spectrums of Antibodies against Aflatoxin
por: Li, Peiwu, et al.
Publicado: (2017)

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens
por: Kraft, John C., et al.
Publicado: (2022)

Increasing temperature denatures canine IgG reducing its ability to inhibit heartworm antigen detection
por: Gruntmeir, Jeff M., et al.
Publicado: (2023)

Systematic generation of in vivo G protein-coupled receptor mutants in the rat
por: van Boxtel, R, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_44pgrk43s5k34mekqlnt3ive89