Application of a Novel Strategy of Engineering Conditional Alleles to a Single Exon Gene, Sox2

BACKGROUND: The Conditional by Inversion (COIN) method for engineering conditional alleles relies on an invertible optimized gene trap-like element, the COIN module, for imparting conditionality. The COIN module contains an optimized 3′ splice site-polyadenylation signal pair, but is inserted antise...

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Detalles Bibliográficos
Autores principales: Mandalos, Nikolaos, Saridaki, Marannia, Harper, Jessica Lea, Kotsoni, Anastasia, Yang, Peter, Economides, Aris N., Remboutsika, Eumorphia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459942/
https://www.ncbi.nlm.nih.gov/pubmed/23029233
http://dx.doi.org/10.1371/journal.pone.0045768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459942/
https://www.ncbi.nlm.nih.gov/pubmed/23029233
http://dx.doi.org/10.1371/journal.pone.0045768

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