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Application of a Novel Strategy of Engineering Conditional Alleles to a Single Exon Gene, Sox2

BACKGROUND: The Conditional by Inversion (COIN) method for engineering conditional alleles relies on an invertible optimized gene trap-like element, the COIN module, for imparting conditionality. The COIN module contains an optimized 3′ splice site-polyadenylation signal pair, but is inserted antise...

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Detalles Bibliográficos
Autores principales:	Mandalos, Nikolaos, Saridaki, Marannia, Harper, Jessica Lea, Kotsoni, Anastasia, Yang, Peter, Economides, Aris N., Remboutsika, Eumorphia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459942/ https://www.ncbi.nlm.nih.gov/pubmed/23029233 http://dx.doi.org/10.1371/journal.pone.0045768

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