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Glycyrrhetic Acid Synergistically Enhances β(2)-Adrenergic Receptor-Gs Signaling by Changing the Location of Gαs in Lipid Rafts
Glycyrrhetic acid (GA) exerts synergistic anti-asthmatic effects via a β(2)-adrenergic receptor (β(2)AR)-mediated pathway. Cholesterol is an important component of the structure and function of lipid rafts, which play critical roles in the β(2)AR-Gs-adenylate cyclase (AC)-mediated signaling pathway....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459958/ https://www.ncbi.nlm.nih.gov/pubmed/23028680 http://dx.doi.org/10.1371/journal.pone.0044921 |