UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Ut...

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Detalles Bibliográficos
Autores principales: Shpargel, Karl B., Sengoku, Toru, Yokoyama, Shigeyuki, Magnuson, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459986/
https://www.ncbi.nlm.nih.gov/pubmed/23028370
http://dx.doi.org/10.1371/journal.pgen.1002964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459986/
https://www.ncbi.nlm.nih.gov/pubmed/23028370
http://dx.doi.org/10.1371/journal.pgen.1002964

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